Publications

CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity

Liu C# *, Shen, M.#, Liu, Y.X., Nishiga, M., Thomas, D., Rhee, J., Sayed, N., Qi, S., and Wu, J.C.

Cell Stem Cell, Volume 31, Issue 12, 1760 - 1776.e9 (# first-author, * corresponding-author)

Death-seq identifies regulators of cell death and senolytic therapies

Colville A, Liu JY, Rodriguez-Mateo C, Thomas S, Ishak HD, Zhou R, Klein JDD, Morgens DW, Goshayeshi A, Salvi JS, Yao D, Spees K, Dixon SJ, Liu C, Rhee JW, Lai C, Wu JC, Bassik MC, Rando TA

Cell Metabolism, 2023 Sep 5:S1550-4131(23)00303-0. doi: 10.1016/j.cmet.2023.08.008.

Statins improve endothelial function via suppression of epigenetic-driven EndMT

Liu C# *, Shen M#, Tan WLW#, Chen IY, Liu Y, Yu X, Yang H, Zhang A, Liu Y, Zhao MT, Ameen M, Zhang M, Gross ER, Qi LS, Sayed N*, Wu JC*

Nature Cardiovascular Research, 2023 May;2(5):467-485. doi: 10.1038/s44161-023-00267-1. (# first-author, * corresponding-author)

Stepwise Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pericytes to Model Coronary Microvascular Dysfunction

Shen M#, Liu C#, Zhao SR, Manhas A, Sundaram L, Ameen M, Wu JC*

Circulation, 2023 Feb 7;147(6):515-518. doi: 10.1161/CIRCULATIONAHA.122.061770. (# first-author, * corresponding-author)

Cardiotoxicity drug screening based on whole-panel intracellular recording

Yang Y, Liu A, Tsai CT, Liu C, Wu JC, Cui B

Biosensors and Bioelectronics, 2022 Nov 15;216:114617. doi: 10.1016/j.bios.2022.114617.

Acoustic Fabrication of Living Cardiomyocyte-based Hybrid Biorobots

Wang J, Soto F, Ma P, Ahmed R, Yang H, Chen S, Wang J, Liu C, Akin D, Fu K, Cao X, Chen P, Hsu EC, Soh HT, Stoyanova T, Wu JC, Demirci U

ACS Nano, 2022 Jul 26;16(7):10219-10230.

Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation

Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC

Cell, 2022 May 12;185(10):1676-1693.e23. doi: 10.1016/j.cell.2022.04.005.

The use of new CRISPR tools in cardiovascular research and medicine

Nishiga M, Liu C, Qi L.S, Wu JC

Nature Review Cardiology, 2022 Feb 10. 505_521.

Editorial: Cardiomyocyte Maturation: Novel Insights for Regenerative Medicine

Zhang M, Qian L, Liu C, Huang GN, Tao G

Frontiers in Cell and Developmental Biology, 2021 Aug 2;9:730622. doi: 10.3389/fcell.2021.730622.

Generation of Human iPSCs by Protein Reprogramming and Stimulation of TLR3 Signaling

Liu C#, Ameen M, Himmati S, Thomas D, Sayed N*

Methods in Molecular Biology, 2021;2239:153-162. doi: 10.1007/978-1-0716-1084-8_10. (# first-author, * corresponding-author)

Single-Cell RNA Sequencing Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells

Paik DT, Tian L, Williams IM, Rhee S, Zhang H, Liu C, Mishra R, Wu SM, Red-Horse K, Wu JC

Circulation, 2020 Nov 10;142(19):1848-1862.

Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

Sayed N#, Liu C#, Ameen M, Himmati F, Zhang JZ, Khanamiri S, Moonen JR, Wnorowski A, Cheng L, Rhee JW, Gaddam S, Wang KC, Sallam K, Boyd JH, Woo YJ, Rabinovitch M, Wu JC*

Science Translational Medicine, 2020 Jul 29;12(554):eaax9276. doi: 10.1126/scitranslmed.aax9276. (# first-author, * corresponding-author)

HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming

Liu C#, Ruan H#, Himmati F, Zhao MT, Chen CC, Makar M, Chen IY, Sallam K, Mocarski ES, Sayed D, Sayed N*

Stem Cell Reports, 2020 Feb 11;14(2):192-200. doi: 10.1016/j.stemcr.2020.01.006. (# first-author, * corresponding-author)

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles

Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC

Cell Stem Cell, 2019 May 2;24(5):802-811.e5. doi: 10.1016/j.stem.2019.02.015.

Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond

Liu C#, Oikonomopoulos A, Sayed N, Wu JC*

Development, 2018 Mar 8;145(5):dev156166. doi: 10.1242/dev.156166. (# first-author, * corresponding-author)

Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine

Sayed N, Liu C, Wu JC

J Am Coll Cardiol, 2016 May 10;67(18):2161-2176. doi: 10.1016/j.jacc.2016.01.083.

Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds

Hou P#, Li Y#, Zhang X#, Liu C#, Guan J#, Li H#, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H*

Science, 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278. (# first-author, * corresponding-author)